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Renal Cystadenocarcinoma and Nodular Dermatofibrosis
Breed: German Shepherd Dog/ Double coat
Generic Phene Data
Breeds
Relevance Rating: There is some evidence or research available for these breeds
Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful in this breed
General
Disease Name
Renal Cystadenocarcinoma and Nodular Dermatofibrosis
OMIA
1335
Gene Name
FLCN
Mutation
c.764A>G
Test Type
Genetic Disease/Disorder
Details
Renal Cystadenocarcinoma and Nodular Dermatofibrosis causes a predisposition to kidney cancer. This condition manifests as a combination of abnormal masses in the kidneys. Owners tend to notice small, hard bumps on thier dog, and signs of kidney disease such as drinking more, frequent urination, blood in the urine, depression, and anorexia. Age of onset around 5-7 years of age, or much older.
Details 2
The disease is characterized by bilateral, multifocal tumors in the kidneys, uterine leiomyomas and nodules in the skin consisting of dense collagen fibers. (Lingaas et al, 2003)
Published
Lingaas, F., Comstock, K.E., Kirkness, E.F., Sørensen, A., Aarskaug, T., Hitte, C., Nickerson, M.L., Moe, L., Schmidt, L.S., Thomas, R., Breen, M., Galibert, F., Zbar, B., Ostrander, E.A. : A mutation in the canine BHD gene is associated with hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis in the German Shepherd dog. Hum Mol Genet 12:3043-53, 2003. Pubmed reference: 14532326. DOI: 10.1093/hmg/ddg336.
Body/System/Process
Renal
OMIA Url
Inheritance
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Breed Specific Info
Researched Breeds
German Shepherd Dog
HSP Test-Specific Data
Wisdom Panel - Kinship
GTP
GTP Name
Wisdom Panel
Breed
OMIA
Gene Name
FLCN
Mutation
c.764A>G
Nature of test
mutation test
FCI Number
166
GTP Breed
German shepherd dog/ Double coat
Weatherbys Scientific
GTP
GTP Name
Weatherbys Scientific
Breed
OMIA
Gene Name
FLCN
Mutation
c.764A>G
VetGen LLC
GTP
GTP Name
VetGen LLC
Breed
OMIA
Gene Name
FLCN
Mutation
c.764A>G
Veterinary Genetics Laboratory
GTP
GTP Name
Veterinary Genetics Laboratory
Breed
OMIA
Gene Name
FLCN
Mutation
c.764A>G
Nature of test
mutation test
GTP- or Breed-Specific Publications
Lingaas, F, KE Comstock, EF Kirkness, A Sørensen, T Aarskaug, C Hitte, ML Nickerson, L Moe, LS Schmidt, R Thomas, M Breen, F Galibert, B Zbar, EA Ostrander.(2003) A mutation in the canine BHD gene is associated with hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis in the German Shepherd dog. Hum Mol Genet 12:3043-53.
Paw Print Genetics
GTP
GTP Name
Paw Print Genetics
Breed
OMIA
Gene Name
FLCN
Mutation
c.764A>G
Nature of test
mutation test
FCI Number
166
GTP Breed
German shepherd dog/ Double coat
Orivet Genetic Pet Care
GTP
GTP Name
Orivet Genetic Pet Care
Breed
OMIA
Gene Name
FLCN
Mutation
c.764A>G
Nature of test
mutation test
FCI Number
166
GTP Breed
German shepherd dog/ Double coat
Genomia s.r.o
GTP
GTP Name
Genomia s.r.o
Breed
OMIA
GTP Disease Synonym
RCND
Gene Name
FLCN
Mutation
c.764A>G
Mutation Comment
g.42186445A>G
EVG Diagnostics
GTP
GTP Name
EVG Molecular Diagnostics
Breed
OMIA
Gene Name
FLCN
Mutation
c.764A>G
DNA My Dog
GTP
GTP Name
DNA My Dog
Breed
OMIA
Gene Name
FLCN
Mutation
c.764A>G
Nature of test
mutation test
This test is outsourced to:
Orivet
FCI Number
166
GTP Breed
German shepherd dog/ Double coat
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