Donate
Search Term: Juvenile Dilated Cardiomyopathy
Breeds
Relevance Rating: There is some evidence or research available for these breeds
Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful for these breeds
Disease Name
Juvenile Dilated Cardiomyopathy
OMIA
-100
Gene Name
cardiac potassium channel gene
Mutation
unpublished
Test Type
Genetic Disease/Disorder
Details
Juvenile dilated cardiomyopathy (JDCM) occurs in Toy Manchester Terriers/English Toy Terriers. It results in sudden cardiac death at a young age, with dogs reported to have passed as early as 10 weeks of age and as late as 1 year of age. Affected dogs usually appear healthy with no signs of heart disease present before the sudden passing. The only external abnormality is that affected male puppies may have unilateral or bilateral cryptorchidism (undescended testicles on one or both sides). For a number of the puppies, their sudden passing occurred within a day of general anesthesia/surgery or exercise.
Details 2
Juvenile dilated cardiomyopathy (JDCM) occurs in Toy Manchester Terriers/English Toy Terriers. It results in sudden cardiac death at a young age, with dogs reported to have passed as early as 10 weeks of age and as late as 1 year of age. Affected dogs usually appear healthy with no signs of heart disease present before the sudden passing. The only external abnormality is that affected male puppies may have unilateral or bilateral cryptorchidism (undescended testicles on one or both sides). For a number of the puppies, their sudden passing occurred within a day of general anesthesia/surgery or exercise. Necropsy (post-mortem examination) may show mild enlargement and dilation of the heart. Microscopic changes include degeneration and scarring of heart tissue and varying degrees of inflammation. Death is presumed to be the result of a sudden fatal arrhythmia (abnormal heart rhythm).
Published
Mol Genet Metab. 2014 Mar;111(3):399-403. doi: 10.1016/j.ymgme.2013.12.002. Epub 2013 Dec 11.
Published 2
Legge CH, López A, Hanna P, Côté E, Hare E, Martinson SA. Histological characterization of dilated cardiomyopathy in the juvenile toy Manchester terrier. Vet Pathol. 2013 Nov;50(6):1043-52. doi: 10.1177/0300985813480509. Epub 2013 Mar 1. PMID: 23456967.
Inheritance
AR
Phene Discovery
Research performed at the University of Minnesota, in collaboration with the University of Pennsylvania and the University of Prince Edward Island, has discovered that JDCM in Toy Manchester Terriers/English Toy Terriers is caused by an autosomal recessive mutation in a cardiac potassium channel.
Researched Breeds
Toy Manchester Terriers, English Toy Terrier
Breed-specific 1
Toy Manchester Terriers, English Toy Terrier
Breed-specific 1 Details
Breed-specific 2
Toy Manchester Terriers, English Toy Terrier
GTPs
Maribor
SI
SI
EVG Diagnostics
In House Testing ISO Accredited/ GTP Other Recognized Accreditation Out Sourced Testing Participant
Spokane, Washington
US
US
Paw Print Genetics
HGTD Leadership Sponsor Test Discovery- GTP In House Testing Non-participant Other Recognized Accreditation Subsidiary Company
St. Paul, Minnesota
US
US
University of Minnesota Canine Genetics Lab
Academic Participant Test Discovery- GTP In House Testing
Vancouver, Washington
US
US
Wisdom Panel - Kinship
HGTD Leadership Sponsor Test Discovery- GTP Other Recognized Accreditation Out Sourced Testing Sponsor-
HGTD Quick Search
-
IPFD Weighs In
...on recent media commentary: Genetics and Genomics for Dogs: Balancing daunting challenges and great potential
-
The HGTD's genetic counselling resources index provides access to basic introductory articles on genetics, articles on application of genetics in breed health management and advanced work in technical genetics research. Breed-specific information is also available in DWN's Pedigreed Dogs Database.
