HGTD Genetic Counselling
This section will contain articles and resources associated with the IPFD's Harmonization for Genetic Testing initiative.
15 articles in this category
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Pure Dog Talk Episode #651 - Bridging the Gap Between Art and Science of Dog Breeding Aimée joins host Laura Reeves to discuss how her work at IPFD is bridging the gap between art and science in dog breeding. They talk about inbreeding and genetic diversity, how those things go together and what you can do when there isn’t a test for a health problem. Click the red arrow below to listen to this episode. Click here to view more details on this episode on the Pure Dog Talk site- IPFD's Harmonization of Genetic Testing for Dogs (HGTD) Project Director, Aimée Llewellyn-Zaidi, joined Laura Reeves for four episodes of her highly-acclaimed Pure Dog Talk Podcast!
About the Pure Dog Talk Podcast
With more than 600+ episodes, 2 million downloads, and 300+ five-star ratings on iTunes, the Pure Dog Talk show is the only leading purebred podcast in the world. Every week, Laura talks to the legends of the sport and gives you the tips and tools to create an awesome life with your purebred dog. #PureDogTalk
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Genetic Profiling (DNA profile or “genetic fingerprint”) The genetic profile of a dog refers to the identification of a set of genetic markers that are specific to an individual dog. These markers remain unique to the dog throughout its life and can be used to unambiguously identify the dog. Different panels of markers have been determined by the International Society of Animal Genetics (ISAG), and the American Kennel Club (AKC) for the purposes of genetic profiling. In additionWhen considering integrating genetic profiling or parentage testing into a registration body, breed club, or breeding plan, it is helpful to start by reviewing the different genetic testing options that are available, and their capabilities and limitations.
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Hover on the video box below to show controls & start Dr. Bell's presentation. 1950082735.mp4Understanding Mixed-Breed and Purebred Populations
WSAVA's November 2020 edition of the Bulletin highlights the work of the WSAVA Hereditary Disease Committee (HDC). For Veterinarians, breed clubs, and breeders see: Understanding Mixed-Breed and Purebred Populations. "Keen to understand more about mixed-breed and purebred populations and how they relate to genetic disease in your patients? Watch this lecture given by WSAVA HDC Chair Dr Jerold Bell at the virtual 2020 AVMA Convention in August (2020)."
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This article is included here to enable readers to better understand the complexities of management of breeding dogs. Collecting and utilizing phenotypic data to minimize disease: A breeder’s practical guide Document TOC A Comparison of Genotypic Tests to Phenotypic Tests Vertical Pedigrees Additional Factors to Consider In Evaluating Vertical Pedigrees Collecting Data for Vertical Pedigrees Building A Personal Data Base Beyond DiseaseCollecting and utilizing phenotypic data to minimize disease: A breeder’s practical guide
Author: Rhonda Hoven
OFA publication. (2003)
While DNA / Genetic tests are becoming increasingly important in management of breeding dogs, it is important to recognize... "DNA tests are not available for the majority of common canine diseases. Most tests intended to offer breeders health information about a dog’s suitability for breeding, rely instead on an evaluation of the dog’s physical status at the time of examination. These are called phenotypic tests, and include evaluations for hip and elbow dysplasia, many eye and cardiac diseases, patella and thyroid disease, and most current canine disease evaluations."
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- Essentials of Health Screening and DNA Testing in Dogs
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Standards, Health and Genetics in Dogs - Chapter II - Genetic testing in dogs - Marie Abitbol (France) Standards, Health and Genetics in Dogs - Chapter II - Genetic testing in dogs - Marie Abitbol (France).pdf Included in this work is discussion of ... Inheritance patterns Genotype-phenotype correlation Genetic counseling matters are addressed! This file is available to DWN members in Downloads.- From - Standards, Health and Genetics in Dogs - Chapter II - Genetic testing in dogs - Marie Abitbol (France) "The first part of this chapter presents the genetic characteristics of the canine species and the basics of canine genetics. The second part addresses the use of screening and diagnostic tests for inherited diseases, with a focus on genetic counselling and the parameters that determine the interpretation of test results. The third part concentrates on the search for informations on canine inherited diseases and the tests available. The final part presents tests for aesthetic characteristics such as coat colour."
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Abstract - In this chapter, we examine the specificities of dog breeding and selection in order to better understand how these practices impact breed health. Selection within the species is characterised by breeding in closed populations, selection objectives that are generally aimed at conformation, animals that receive substantial veterinary care, selection that is often empirical using a small number of breeding dogs and, more occasionally, the use of practices such as mating between close re- Here we are pleased to present a Chapter from the Book - Standards, Health and Genetics in Dogs/Standards, Santé et Génétique chez le Chien GUINTARD C. and LEROY G. [Dir.], Standards, Health and Genetics in Dogs
/ Standards, santé et génétique chez le Chien /, FCI-SCC-SKK ed., 2017, ISBN : 9 782746 696730, 400 p. Relationships between genetics, breeding practices and health in dogs - Grégoire Leroy (France) English and French versions are available.
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Introduction Participants reflected a broad segment of stakeholders in canine health, including veterinarians, genetic test providers (GTPs), and researchers, as well as dog owners and/or breeders, kennel/breed club representatives and canine health campaigners. The 4th IDHW was organized to immediately follow the 10th ICCFGG meeting in Bern. This ensured broader representation of the research community at the IDHW and presentation of an IPFD poster at the Bern meeting. These various effo- This report is to be viewed as a dynamic document summarizing the pre-thru-post 4th IDHW meeting activities around the Genetic Testing theme. Please note that additions and changes may occur. We will be welcoming comments and suggestions from participants in the workshop and working groups as we move forward. Please contact Aimee at aimee.llewellyn-zaidi@ipfdogs.com.
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In this paper health conscious breeding, the role of genetic testing and the importance of genetic counseling are addressed. See additional information on WASAV's Hereditary Disease Committee... WSAVA Resources on hereditary disease Also see: WSAVA Animal Welfare Guidelines for companion animal practitioners and veterinary teams (2018) WSAVA-Hereditary-Disease-Committee_Position-Paper-(2018) (Internal)- As we have seen, veterinarians and their organizations have been engaging significantly in aspects of health in breeds and healthy breeding. Here is a recent position paper, The Role of Health Conscious Breeding and Genetic Testing in Reducing the Impact of Hereditary Disease, from the World Small Animal Veterinary Association (WSAVA). The Hereditary Disease Committee of the WSAVA is an IPFD Collaborator.
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Dog Breeding Reform group's inaugural meeting - Lecture and Slides- From the Dog Breeding Reform group's inaugural meeting...DBRG 2017 22 October 2017 at 13:18:18 Lecture - video and slides Terms and concepts...Multifactorial traits, Genetic factors, Environmental factors, Threshold effect, Lafora’s disease, MWHD, Degenerative Myelopathy, whole breed management, Simple (single gene), Complex, Single gene disorder, Simple autosomal recessive, Homozygous clear, Heterozygote (carrier), Homozygous affected, coat colours, incompletely penetrant autosomal recessive, Complex inheritance, Polygenic traits, Wobblers, Diagnostic test may expensive and/or inconclusive, Effect of environment / other factors, standards, epigenetics, immune mediated disease and more...
What tests are available? There are many different kinds of genetic tests available. Below, you can see a short summary of the more common types of tests. Individual mutation tests – this test is undertaken for a specific phene (i.e. a specific disease or attribute) Ex: for an individual eye disease Combined Individual tests – these are often individual phenes that are tested for in combination. These tests can occur where there is more than one mutation that can relate to the d- This introduction to genetic testing can tell you more about the different types of testing that are available, and guidance on what resources can help you find, choose, and use, the right tests for your dog.
Aren't all test providers the same? There are a lot of different choices of genetic test providers (GTPs), so choosing one that is trustworthy and also providing the service you need, can be daunting. Currently, there is no single international standard that covers the quality of tests provided, how tests are performed, or how test results are reported, and genetic advice/counselling. This means that very robust test providers can initially be hard to pick out from the crowd. Even though there- Choosing a genetic test provider can be daunting. This short article helps you to consider what is important to you, and your dogs, in finding the right test provider for you.
- The increasing availability of genetic screening tests, DNA tests, and now multiplex test panels also requires an understanding of what the tests tell you.
View this presentation and learn:
- The practical applications for using the results of these tests to improve the health of dogs
- The dangers for the inappropriate use of genetic tests to dog health
- The roles of the breeder, dog owner and veterinarian in utilizing genetic tests
This is not a comprehensive listing - it is a starting point for finding relevant resources on DogWellNet.
Overview of Genetic Testing resources
https://dogwellnet.com/content/hot-topics/genetic-testing-r509/
COMMON GENETIC TERMS Allele: a variant form of a gene. Allele frequency: the fraction of all the alleles of a gene in a population that are of one type. Carrier: an individual who carries and is capable of passing on a genetic mutation associated with a disease and may or may not display disease symptoms. Carriers are associated with diseases inherited as recessive traits. In order to have the disease, an individual must have inherited mutated alleles from both parents. An individ- Basic Genetics TermsSources of terms/definitions: (Note: in some cases term definitions are quoted directly; in others the term definition language was adjusted, the word 'dog' substituted for people/human) National Human Genome Research Institute (NHGRI)Glossary: https://www.genome.gov/glossary/index.cfm?showall=true; Genetics Home Reference: https://ghr.nlm.nih.gov/primer; Understanding Genetics: A District of Columbia Guide for Patients and Health Professionals. Appendix B Classic Mendelian Genetics (Patterns of Inheritance): https://www.ncbi.nlm.nih.gov/books/NBK132145/ OFA Glossary: https://www.ofa.org/about/educational-resources/glossary A Glossary of Genetic Terms - Dr. John Armstrong: http://www.dogenes.com/essays/glossary.html
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