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The Genetics Behind OSD 1.0.0


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About This File

Oculoskeletal dysplasia

Canine genetics research at the Animal Health Trust
• Basic genetics
• Finding disease mutations
• Genetics of OSD – Part 1 –
        Identifying the causal mutation
• Genetics of OSD – Part 2 –
       Implications for the breed
• Summary and Breeding Advice
• Acknowledgements
• OSD3 DNA Test

Breeds information/impacts...

- the drd1 mutation in the gene COL9A3 in the Labrador retriever
- the drd2 mutation in the gene COL9A2 in the Samoyed - autosomal recessive mode of inheritance of the complete phenotype

• Clinical findings in the Labrador retriever & in the Samoyed
  (Carrig et al. 1988 & Goldstein et al. 2010)
- disproportionate dwarfism
- corneal opacities, cataracts, persistent hyaloid artery remnants, vitreal dysplasia, alterations in optic nerve head colour + size, retinal dysplasia retinal detachment
• Recently observed in 7 Northern Inuit Dogs (NID)

 

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  • International Dog Health Workshops

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  • Our Partners

    • A Continuing and Sustainable Development The International Partnership for Dogs (IPFD) and DogWellNet.com have come into being following a long history of efforts by many stakeholders to address dog health and well-being. An abbreviated timeline of key developments will highlight the complexity of issues addressed by the IPFD and DogWellNet and will list some of the many supporters and collaborators that have contributed directly or indirectly to this important work. Development was inaugurated under the patronage of the Fédération Cynologique Internationale (FCI). The major contributors (in-kind and funding) since 2011 have been, chronologically, the Agria Animal Insurance
    • Our mission is to safeguard the health and wellbeing of your pet with fully personalised, breed-specific care. Orivet was founded on the premise that each and every pet is unique, with its own set of specific traits, behaviours, genetic health needs and inherent risks. We work with pet owners, breeders and vets to provide completely personalised products and services that treat and care for pets as the unique individuals they are, taking into account each pet’s genetic makeup, age, sex and lifestyle.   Through this we aim to encourage the development of a deep, genuine and lasting bond between pets and their owners.   Orivet is a proud sponsor of IPFD's Harmonizatio
    • Utilising the latest DNA technologies has enabled the VHLGenetics to grow exponentially since 1993.   Our experienced laboratories offer more than 1,000 routine DNA tests for animals, plants and microorganisms. The three locations offer the same DNA services, and the number of DNA tests available is routinely increased by the newest developments in the field.     VHLGenetics is a proud sponsor of IPFD's Harmonization of Genetic Testing for Dogs Initiative.          
    • IPFD has endorsed the Global Pet Obesity Initiative Position Statement, joining 24 International Veterinary Professional Organizations, including the American Veterinary Medical Association Board of Directors, British Small Animal Veterinary Association, Canadian Veterinary Medical Association, World Small Animal Veterinary Association, and others.
    • See a selection of Press articles related to IPFD's Harmonization of Genetic Testing HERE.
    • The Black Russian Terrier Club of America (BRTCA) is the AKC Parent Club for the Black Russian Terrier. BRTCA's mission is to do all in its power to protect and advance the interests of the breed and to encourage sportsmanlike competition at conformation shows, companion events and performance trials.    
    • Headquartered in Denver, Colorado, Morris Animal Foundation is the largest nonprofit foundation in the world dedicated to funding studies to improve and protect the health of companion animals and wildlife. Since its establishment in 1948, the Foundation has invested $126 million toward more than 2,600 studies that have led to significant breakthroughs in disease, toxic exposures and injury diagnostics, treatments and preventions to benefit animals worldwide.  
    • The SKK - Svenka Kennelklubben (Swedish Kennel Club, in English), is Sweden's largest organisation dedicated to dogs and dog owners. We represent the interests of our 300,000 members – first time dog owners, experienced breeders, hunters, dog lovers, puppy buyers, exhibitors, agility competitors and many more.   Website: http://www.skk.se/en/ Database: Avelsdata Follow this link for the SKK Blog at DogWellNet Follow this link for more information on the Swedish Kennel Club including our organizational structure, code of ethics, and more.
    • Our laboratory provides a complete testing service for veterinary surgeons to meet the diagnostic needs of your practice.     LABOKLIN is a proud sponsor of IPFD's Harmonization of Genetic Testing for Dogs Initiative.      
    • Canine Medicine and Genetics is a peer-reviewed, open access journal addressing genetic, genomic and epidemiological research in both domestic and wild canids, relating to breed and species diversity, and canine evolution.  
    • The OFA was a Founding Partner of the International Partnership for Dogs and an Initiating Partner for the HGTD Initiative. See OFA's About Us page at: https://www.ofa.org/about The OFA is a participant in the IPFD's Harmonization of Genetic Testing for Dogs Initiative.      
    • The World Small Animal Veterinary Association (WSAVA) is an association of associations. Its membership is made up of veterinary organisations from all over the world, which are concerned with companion animals.     The Hereditary Diseases Committee of the WSAVA is collaborating on the IPFD Harmonization of Genetic Testing for Dogs initiative.   Website: www.wsava.org    
    • The Kennel Club is the largest organization in the UK devoted to dog health, welfare and training. Its objective is to ensure that dogs live healthy, happy lives with responsible owners.   Website: http://www.thekennelclub.org.uk  
    • The Animal Health Trust was a proud sponsor of IPFD's Harmonization of Genetic Testing for Dogs Initiative.        
    • IPFD is a truly "people driven" service organization. Our structure and resources (a modest budget and small group of consultants, volunteers, and Board Members) facilitate the activities of our stakeholders to achieve our individual and collective priorities for the health and welfare of dogs. As a growing, independent voice within the global dog community, we aim to provide the best possible information and advice to assist our stakeholders in making optimal decisions for their members, customers, and breed(s) of interest. IPFD provides and supports a ‘big picture’, balanced, transparent and integrated approach to the complex challenges for dogs and the people who care about them.
    • This year has been challenging for all organizations globally.  However, IPFD has fared well.  We have always been a ‘virtual’-based operation, with all consultants working from home.  Building on our 2019 Annual Report: A Growing Voice, this milestones document is meant to update our Partners and Sponsors on our activities in 2020. – Dr. Brenda Bonnett, CEO (click to download/share as a PDF): IPFD Milestones December 2020.pdf   Message from the Canadian Kennel Club: “CKC’s membership in the International Partnership for Dogs, and participation in the biennial Dog Health Workshop and the international working group for extremes in conformation has strengthened
    • Website: http://www.akc.org
    • The Canadian Kennel Club (CKC) is the primary registry body for purebred dogs in Canada and currently recognizes 175 breeds. As a non-profit organization, the CKC is dedicated to encouraging, guiding, and advancing the interests of purebred dogs and their responsible owners and breeders in Canada and promoting the knowledge and understanding of the benefits which dogs can bring to Canadian society.  
    • Suomen Kennelliitto (Finnish Kennel Club, in English) - Established in 1889, the Finnish Kennel Club is a nationwide expert organisation on canine matters. Its aim is to promote the breeding of pedigree dogs, support diverse dog-related activities and improve dog-keeping standards in Finland. FKC disseminates expert information and serves as a comprehensive lobbying organisation for Finnish and international dog activities.   Website: https://www.kennelliitto.fi/en FKC Database: KoiraNet-jalostustietojärjestelmä: https://jalostus.kennelliitto.fi/ PEVISA: https://www.kennelliitto.fi/kasvatus-ja-terveys/pentueen-rekisterointi/kaikkia-rotuja-koskevat-rekisterointiehdot-pevisa-j
    • Mission Facilitate collaboration and sharing of resources to enhance the health, well-being and welfare of pedigree dogs and all dogs worldwide. Vision An enduring global collaboration enhancing dog health, well-being and welfare, and human-dog interactions. Values Dog health, well-being and welfare and human-dog interactions contribute to the quality of life for both species. The world is a better place because we share it with dogs. Dog issues are important around the globe and international sharing and cooperation is needed. Goals The general goals of the IPFD are to:  Enhance the health, well-being and welfare of dogs and enri
    • ANTAGENE develops, produces and markets DNA tests for parentage certification and disease prevention in dogs and cats. The company is based near Lyon (France) and has a staff of 18 people. ANTAGENE offers more than 100 DNA tests in some 50 countries around the world. ANTAGENE solutions have been used by more than 80,000 breeders and veterinarians the world over.   . ANTAGENE was an initiating sponsor of IPFD's Harmonization of Genetic Testing for Dogs Initiative.    
    • The Irish Kennel Club promotes the responsible ownership and breeding of dogs throughout Ireland through education, registration, training and support schemes and events.   Website: http://www.ikc.ie/ Irish Kennel Club Blog at DogWellNet: - under construction -
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